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. Author manuscript; available in PMC: 2016 Jul 8.
Published in final edited form as: Oncogene. 2015 Sep 21;35(22):2932–2947. doi: 10.1038/onc.2015.345

Figure 11. LRIG1 expression in Met receptor positive Basal B breast cancer cells is as effective as Met inhibition.

Figure 11

(A) Left panel: Western blot analysis of total cell lysates from MDA-MB-231-pMX control and –LRIG1 cells, treated with and without 0.5 uM ARQ197 for 24 hours, as indicated. Right panel: Western blot analysis of total cell lysates from MDA-MB-157-pMX control and –LRIG1 cells, treated with and without 0.5 uM ARQ197 for 24 hours, as indicated. (B) Migration of pMX control and LRIG1-expressing MDA-MB-231 (top panel) and MDA-MB-157 (bottom panel) cells with and without 0.5 μM ARQ197 was measured after 12 hrs by Boyden chamber transwell migration assay. Data are presented as mean ± SEM, collected from at least 3 independent experiments (** = p<0.01–0.001, *** = p<0.001 by Student’s t-test).