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. Author manuscript; available in PMC: 2016 Jul 8.
Published in final edited form as: Oncogene. 2015 Sep 21;35(22):2932–2947. doi: 10.1038/onc.2015.345

Figure 12. LRIG1 inhibits growth of MDA-MB-231 breast cancer cells in vivo.

Figure 12

Figure 12

(A) MDA-MB-231-pMX and MDA-MB-231-pMX-LRIG1 cells were xenografted into the mammary fat pad of NOD.SCID female mice and tumor volume was followed over time with caliper measurement. Data are presented as mean ± SEM, * = p<0.05 by two-way ANOVA. (B) Immunohistochemical (IHC) and hematoxylin and eosin (H&E) staining of primary tumors and metastatic lesions, as indicated. Top row: pMX (control) cell xenograft. #1–3: Representative primary tumors and matched metastatic lesions from LRIG1 xenografts. Scale bar = 20 μm.