Table 3.

Summary of fever clearance time by Salmonella Typhi lineage and ciprofloxacin susceptibility.

DOI: http://dx.doi.org/10.7554/eLife.14003.007

Fever clearance time	Gatifloxacin median (IQR) days	Ceftriaxone median (IQR) days	Acceleration factor (95%CI); p value	Heterogeneity test (p value)
H58¥				0.07
- H58	5.03 (3.18, 7.21)	3.07 (1.89 ,4.52)	1.59 (1.22, 2.09); p=0.0006
- Non-H58	2.87 (2.08, 3.7)	3.12 (2.2, 4.12)	0.90 (0.59, 1.36); p=0.61
Ciprofloxacin susceptibility group‡				0.015
- Susceptible	2.96 (2.13, 3.85)	4.78 (4.01, 5.5)	0.71 (0.49, 1.02); p=0.07
- Intermediate	4.01 (2.76, 5.37)	2.63 (1.52, 4.05)	1.31 (0.97, 1.76); p=0.07
- Resistant	8.2 (5.99, 10.5)	3.83 (2.96, 4.7)	2.23 (1.57, 3.17); p<0.0001

^¥p=0.013 and p=0.029 for comparison of interval censored time to fever clearance between H58 vs. non-H58 groups in gatifloxacin arm only and in all patients, respectively.

^‡p<0.0001 for comparison of interval censored time to fever clearance between MIC groups in gatifloxacin arm only.