Figure 7. Summary.

(A) Simplified diagram of granule cell (GC) input patterns to three Purkinje cell (PC) clusters. Zebrin bands are indicated with dotted lines. GC color indicates its postsynaptic target while white indicates either no target or an unknown target. Contiguous PCs display similar input patterns and each PC cluster presents a stereotyped input pattern. In the anterior vermis of lobule III/IV, some regions of the GC layer project to all recorded PCs (black arrows, for example in ipsilateral P2⁺ or P1⁺), while others can target a single PC cluster (white arrow). (B) Within a given microzone, the different cell types do not show the same GC input pattern. In cluster 1, PCs and molecular interneurons (MLIs) are sometimes contacted by GCs from the same region (either distal GCs, gray arrow, or local GCs, gray circle), while some groups of GCs contact either PCs (black arrow) or MLIs (white arrow). GoCs are mainly contacted by local inputs (gray circle) and implement local feedback inhibition.

DOI: http://dx.doi.org/10.7554/eLife.09862.015

Figure 7—figure supplement 1. Mean histogram of normalized amplitude of granule cell inputs aligned on PC soma (see Discussion).

(A) To test how cell position can affect the median granule cell (GC) input patterns, we centered all recorded Purkinje cells (PCs) and calculated the median Z-score as previously described. Note the absence of a secondary peak. (B) Centered, normalized representation of the mean amplitude using our dataset shows results similar to those in a previous study (Walter et al., 2009)

DOI: http://dx.doi.org/10.7554/eLife.09862.016