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. 2016 Mar 24;10:74. doi: 10.3389/fncel.2016.00074

Figure 1.

Figure 1

Enhanced intrinsic excitability in cultured prion protein (PrP)-null neurons. (A) Representative action potentials (APs) evoked by depolarizing pulses in a hippocampal neuron cultured from wild-type (WT; black) and PrP-null mice (red). (B) Average number of APs induced by increasing depolarizing currents in cultured neurons from WT (n = 13) and PrP-null mice (n = 10). (C) Average spike threshold for WT and PrP-null neurons. (D) APs evoked by a 500 ms depolarizing current ramp for WT (black) and PrP-null (red) neuron. (E) Cumulative AP latencies for WT and PrP-null neurons (p < 0.001 for the induced AP from the first to the seventh). (F) Average number of APs during current ramp application for WT (n = 6) and knock-out (KO) neurons (n = 7). *p < 0.05, ***p < 0.001.