Table 1.
GPCRs that have resolved crystal structures in a timeline.
| Year | Proteins |
|---|---|
| 2000 | Bovine rhodopsin (1F88), Palczewski et al. (2000) |
| 2007 | Human β2AR (2RH1), Rasmussen et al. (2007) |
| 2008 | Turkey β1AR (2VT4), Warne et al. (2008); Squid rhodopsin (2Z73), Murakami and Kouyama (2008); Human A2A AR (3EML), Jaakola et al. (2008) |
| 2010 | Human CXCR4 (3ODU), Wu et al. (2010); Human D3R (3PBL), Chien et al. (2010) |
| 2011 | Human H1R (3RZE), Shimamura et al. (2011) |
| 2012 | Human M2 AchR (3UON), Haga et al. (2012); Human S1PR (3V2Y), Hanson et al. (2012); Human M3 AChR (4DAJ), Kruse et al. (2012); Human KOR (4DJH), Wu et al. (2012); Mouse MOR (4DKL), Manglik et al. (2012); Human N/O FQR (4EA3), Thompson et al. (2012); Mouse DOR (4EJ4), Granier et al. (2012); Rat NTSR1 (4GRV), White et al. (2012); Human CXCR1 (2LNL), Park et al. (2012); Human PAR1 (3VW7), Zhang et al. (2012b) |
| 2013 | Human 5-HT2BR (4IB4), Wacker et al. (2013); Human 5-HT1BR (4IAR), Wang et al. (2013a); Human SMOR (4JKV), Wang et al. (2013b); Human CRFR1 (4K5Y), Hollenstein et al. (2013); Human GCGR (4L6R), Siu et al. (2013); Human CCR5 CR Tan et al. (2013) |
| 2014 | Human GluR1 (4OR2), Wu et al. (2014); Human P2YR12 (4NTJ), Zhang et al. (2014); Human GluR5 (4OO9), Doré et al. (2014); Human GPR40 (4PHU), Srivastava et al. (2014) |
| 2015 | Human OX2 (4S0V), Yin et al. (2015); Human DOR (4RW4), Fenalti et al. (2015); Human P2YR1 (4XNW), Zhang et al. (2015a); Human AT1R (4YAY), Zhang et al. (2015b) |
Abbreviations: GPCRs, G protein-coupled receptors; β1/β2AR, β1/β2 adrenergic receptor; A2A AR, adenosine A2A receptor; CXCR4, C-X-C chemokine receptor type 4; D3R, D3 dopamine receptor; H1R: histamine H1 receptor; M2/M3 AChR, M2/M3 muscarinic acetylcholine receptor; S1PR, sphingosine-1 phosphate receptor; K/M/DOR, kappa/mu/delta opioid receptor; N/O FQR, nociceptin/orphanin FQ receptor; NTSR1, neurotensin receptor type 1; CXCR1, CXC chemokine receptor 1; PAR1, protease-activated receptor; 5-HT1B/2BR, 5-hydroxytryptamine receptor type 1B/2B; SMOR, smoothened receptor; CRFR1, Corticotropin-releasing hormone receptor 1; GCGR, glucagon receptor; CCR5 CR, C-C chemokine receptor type 5; GluR1/5, glutamate receptor type 1/5; P2YR1/12, purinergic G protein-coupled receptor 1/12; GPR40, G protein-coupled receptor 40; OX2, Orexin receptor type 2; AT1R, Angiotensin II type 1 receptor.