Figure 3.

Distribution of the [⁶⁴Cu]Cu-DOTATATE in mice bearing MPC-mCherry tumors; radiotracer accumulation was blocked by co-injection of octreotide, [^natLu]Lu-DOTATATE and AN-238 at 0.2 µmol/kg; (A) FLI of tumors; (B) PLI of radiotracer distribution; (C) PET maximum intensity projections of radiotracer distribution; (D) radiotracer accumulation in tumors as determined in PLI studies; (E) radiotracer accumulation in tumors as determined in PET studies; (F) radiotracer accumulation in organs and tumors as determined in ex vivo radiotracer distribution studies; (tu) tumor; (bl) bladder; data are presented as means ± SEM; significance of differences was tested as compared to control; * p < 0.05; † p < 0.01; ‡ p < 0.001.