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. 2016 Mar 10;6(5):650–665. doi: 10.7150/thno.14479

Figure 4.

Figure 4

Progression of MPC-mCherry tumors in mice undergoing doxorubicin (6.9 µmol/kg), AN-238 (0.2 µmol/kg), and [177Lu]Lu-DOTATATE (80 MBq/animal) treatment; (A) mCherry FLI/X-ray overlays of tumor-bearing mice after 15 and 30 days pci; (B) monitoring of tumor volume; (C) monitoring of 177Lu activity in tumors after [177Lu]Lu-DOTATATE treatment as determined by PLI; (177Lueff/corr) effective and decay-corrected 177Lu activity; (D) [177Lu]Lu-DOTATATE PLI after 16 days pci; (E) [177Lu]Lu-DOTATATE SPECT after 16 days pci; (↓) treatment start; data are presented as means ± SEM; significance of differences was tested as compared to control after 30 days pci; * p < 0.05; † p < 0.01; ‡ p < 0.001.