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. 2016 Mar 20;6(5):726–738. doi: 10.7150/thno.14514

Figure 5.

Figure 5

Monitoring of thrombolysis via molecular ultrasound imaging showed a theranostic effect and a reduction of thrombus size after the injection of TT-MB. A. A reduction of thrombus size was observed for animals administered with LIBS-MB and high dose of commercial uPA at 500U/g BW (black line and B) as compared to LIBS-MB and saline (blue line and C) as vehicle control. A reduction of thrombus size was also observed with TT-MB (red line and D) as compared to LIBS-MB and low dose of commercial uPA at 75U/g BW (light grey line and E). Baseline area was set to 100% and areas were calculated every 5 min for 45 min. Thrombus size was traced and calculated using VisualSonics software. Treatment groups were compared by use of repeated measures ANOVA over time with Bonferroni post tests at each time point (Mean % ± SEM; **p<0.01, ***p<0.001, n≥3 each).