Figure 8.

Bleeding time in mice determined by tail transection shows that there is no bleeding time prolongation at the effective dose of TT-MB. LIBS-MB with commercial uPA at 500U/g BW demonstrated considerably longer bleeding time as compared to LIBS-MB with saline vehicle control (*p<0.001, n=4 each). TT-MB, LIBS-MB with low dose commercial uPA at 75U/g BW and saline control did not prolong bleeding time. These assays were analyzed with one-way repeated measures ANOVA with the Bonferroni post test.