Table 2.
Clinical variables: symptoms and laboratory findings in Cronkhite–Canada syndrome
| Symptoms | At initial diagnosis (%) | Overall frequency (%) | |
|---|---|---|---|
| Diarrhea | 70.0 | 78.3 | |
| Dysgeusia | 64.8 | 81.3 | |
| Alopecia | 49.0 | 80.0 | |
| Onychodystrophy | 64.4 | 89.0 | |
| Hyperpigmentation | 48.8 | 70.1 | |
| Bleeding | 1.44 | 9.6 | |
| Intussusception | 0.96 | 4.8 |
| Laboratory findings | At initial diagnosis | After initial treatment | p b |
|---|---|---|---|
| Hemoglobin (g/dl) | 13.0 ± 2.49 | 13.9 ± 2.02 | 0.68 |
| Total protein (g/dl) | 5.35 ± 0.94 | 6.37 ± 0.88 | <0.01 |
| Albumin (g/dl) | 2.96 ± 0.74 | 3.83 ± 0.63 | <0.01 |
| Total cholesterol (mg/dl) | 147.2 ± 34.9 | 196.9 ± 42.0 | <0.01 |
| C-reactive protein (mg/dl) | 0.94 ± 2.53 | 0.16 ± 0.38 | <0.01 |
| Laboratory findings | At initial diagnosis | Normal range | |
|---|---|---|---|
| IgG (n = 91) | 812.6 ± 296.2 mg/dl | 680–1620 mg/dl | |
| Positive ANA test result (n = 72) | 27.7 % | ||
| Zinc (n = 65) | 73.6 ± 21.7 μg/dl | 80–160 μg/dl | |
| Elevated α1-antitrypsin clearance (n = 30) | 93.3 % | <20 ml/day | |
| Positive 99mTc-albumin scintigraphy finding (n = 56) | 75 % | ||
| Helicobacter pylori positivity (n = 113)a | 54.0 % |
Total of 210 patients.
ANA antinuclear antibodies
aDiagnostic testing for H. pylori was performed with one of or a combination of rapid urease testing, culture, histology, IgG antibodies to H. pylori, or fecal antigen.
bStatistical comparison laboratory data between “at initial diagnosis“ and “after initial treatment”