Table 2.

PROMIS score distributions and statistical model results

	Anxiety	Depression	Fatigue	Pain interference	Physical function
Mean score scale mean	2.46	1.95	2.84	2.67	3.93
Mean score scale 25th percentile	1.75	1.00	2.25	1.66	3.30
Mean score scale 50th percentile	2.50	1.75	2.75	2.66	4.00
Mean score scale 75th percentile	3.00	2.50	3.50	3.66	4.75
T-score scale mean	56.80	51.94	55.96	58.11	44.40
T-score scale 25th percentile	52.10	38.20	51.50	53.20	38.90
T-score scale 50th percentile	58.40	53.20	55.60	59.50	43.10
T-score scale 75th percentile	62.50	58.20	61.30	64.80	49.60
Multi-level mixed-effects models (deceased patients only)
Linear model
Linear term p value	0.6367	0.8048	0.0001	0.0005	<0.0001
Quadratic model
Linear term p value	0.4207	0.0599	<0.0001	<0.0001	<0.0001
Quadratic term p value	0.5055	0.0545	0.0038	0.0018	<0.0001
Spline model
Linear term p value	0.2301	0.3679	0.4053	0.6804	0.1371
Spline term part 1 p value	0.0393	0.0236	0.3653	0.5419	0.0593
Spline term part 2 p value	0.0061	0.0008	0.0175	0.0205	0.4479
Probability of information loss by excluding non-linear terms	0.1353	1.0000	1.0000	1.0000	1.0000
Cox regression models (all patients)
Score term p value	0.8692	0.0005	<0.0001	<0.0001	<0.0001
Survival curve homogeneity over score quartiles log-rank p value	0.1033	0.0189	0.0031	<0.0001	<0.0001
Probabilities of survival
25th percentile at 6 months	0.95	0.96	0.98	0.98	0.89
50th percentile at 6 months	0.91	0.93	0.95	0.94	0.96
75th percentile at 6 months	0.94	0.92	0.91	0.90	0.99
25th percentile at 12 months	0.80	0.82	0.87	0.87	0.72
50th percentile at 12 months	0.77	0.79	0.82	0.80	0.83
75th percentile at 12 months	0.79	0.76	0.73	0.73	0.89