Table 3.
Baseline characteristics of the patients involved in the multivariate analysis according to the Ang-2 level (n=109)
|
|
||||
|---|---|---|---|---|
| n | Ang-2 < 5 ng/mL (n=69) | Ang-2 >=5 ng/mL (n=40) | p† | |
| Age — years ‡ | ||||
| <= 65 | 56 | 31 (45) | 25 (63) | |
| >65 | 53 | 38 (55) | 15(37) | 0.11 |
|
| ||||
| Sex‡ | ||||
| Male | 45 | 39 (57) | 25 (63) | |
| Female | 64 | 30 (43) | 15 (37) | 0.54 |
|
| ||||
| Performance status OMS‡ | ||||
| 0 | 57 | 41 (59) | 16 (40) | |
| >0 | 52 | 28(41) | 24 (60) | 0.07 |
|
| ||||
| Primary Tumor site‡ | ||||
| Colon | 73 | 46(67) | 27 (68) | |
| Rectum | 36 | 23(33) | 13 (32) | 0.93 |
|
| ||||
| Timing to metastasis ‡ | ||||
| Synchronous | 74 | 39 (57) | 35 (92) | |
| Metachronous | 32 | 29 (43) | 3 (8) | < 0.0001 |
|
| ||||
| Metastases localisation‡ | ||||
| Liver alone | 43 | 28 (41) | 15 (37) | |
| Liver and other | 58 | 33 (48) | 25 (63) | |
| Other alone | 8 | 8 (12) | 0 (0) | 0.04515 |
|
| ||||
| Surgery of the primary tumor ‡ | ||||
| No | 73 | 16 (24) | 18 (46) | |
| Yes | 34 | 52 (76) | 21 (54) | 0.0189 |
|
| ||||
| Leucocyte (×106/mL)* | 89 | 7.3713±2.3972 | 9.4180± 3.8269 | 0.0026 |
|
| ||||
| Lymphocyte (×106/mL)* | 85 | 1.6589±0.6355 | 1.2187±0.5816 | 0.0017 |
|
| ||||
| LDH ‡ | ||||
| <=350 (ULN) | 52 | 43 (62) | 9 (23) | |
| >350 (ULN) | 57 | 26 (38) | 31 (77) | < 0.0001 |
|
| ||||
| GERCOR score‡ | ||||
| 0 Low-risk | 32 | 29 (42) | 3 (7) | |
| 1 Intermediate-risk | 45 | 26 (38) | 19 (48) | |
| 2 High-risk | 32 | 14 (20) | 18 (45) | 0.0002 |
*
Plus–minus values are means ±SD and the unpaired t-test was used for the comparison of variable among groups.
†
P values are for the comparison between cohort set 1 and cohort set 2 populations
‡
Chi-square or Fisher exact tests were used for the comparison of categorical variables,.
Abbreviations: PS, performance status
Bold characters represent significative results.