Table 3. Expression levels and related functions of the six selected human miRNAs^a.

miRNA	Discovery stage: FCb				Validation stagec			Relevant functions	Sources
	CBP/Non	CBP/Exp	Exp/Non		CBP/Non	CBP/Exp	Exp/Non
let-7d-5p	−1.21	−0.71	−0.50		0.25 (0.12, 0.55)	0.30 (0.15, 0.67)	0.49 (0.15,0.97)	RAS regulation; regulation of iron metabolism in erythroid cells	(19,20)
miR-24-3p	1.50	1.87	−0.37		3.52 (1.85, 5.94)	3.31 (1.74, 5.59)	0.69 (0.35, 1.22)	PAHs response; DNA damage response; ARNT regulation	(13)
miR-122-5p	−1.99	−1.22	−0.76		0.07 (0.03, 0.09)	0.12 (0.06, 0.16)	0.32 (0.18, 0.51)	Heme oxygenase-1 regulation	(21)
miR-221-3p	1.15	2.16	−1.01		3.96 (1.77, 8.05)	11.92 (5.33, 24.23)	0.23 (0.14, 0.45)	low-level hydroquinone response	(22)
miR-223-3p	−0.83	−1.17	0.35		0.52 (0.18, 1.37)	0.34 (0.11, 0.88)	0.59 (0.36, 1.77)	Environmental cigarette smoke (ECS) response	(21)
miR-638	−1.07	−2.08	1.01		0.20 (0.13, 0.42)	0.06 (0.04, 0.12)	2.20 (0.89, 4.98)	Benzo(a)pyrene response; regulation of differentiation and proliferation in leukemic cells	(23,24)

^a, Non = non-exposure and Exp = Exposure; ^b, the fold change value underwent a Log₂-transformation; ^c, values are median (25^th percentile, 75^th percentile) qRT-PCR expression relative to cel-miR-238. qRT-PCR, quantitative reverse-transcription polymerase chain reaction.