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| Toxicity | Dose level 1 (n=3) 1/2/3/4 | Dose level 2 (n=3) 1/2/3/4 | Dose level 3 (n=6) 1/2/3/4 |
|---|---|---|---|
| Anaemia | 1/1/0/0 | 3/0/0/0 | 2/3/0/0 |
| Leukopenia | 2/1/0/0 | 2/1/0/0 | 3/2/1/0 |
| Neutropenia | 3/0/0/0 | 2/1/0/0 | 4/2/0/0 |
| Thrombocytopenia | 0/0/0/0 | 0/1/0/0 | 1/1/1*/0 |
| Esophagitis | 0/3/0/0 | 0/3/0/0 | 0/3/3*/0 |
| Pneumonitis | 1/1/0/0 | 0/1/0/0 | 1/1/1*/0 |
| Nausea | 1/0/0/0 | 2/1/0/0 | 5/1/0/0 |
| Diarrhoea | 0/0/0/0 | 0/0/0/0 | 0/1/0/0 |
| Anorexia | 1/1/0/0 | 2/1/0/0 | 4/2/0/0 |
*, DLT, dose-limiting toxicity.
