Cartoon of trimeric transporter based on an all-atom model (see Tsigelny et al. (31)). Each monomer of the active trimer are shown in red, cyan, or purple. The putative Cu-coordinating residues, extracellular, Met-43, Met-45, intramembrane, Met-150, Met-154, and intracellular His-188-Cys-189-His-190, in green. His-139 is shown in blue. The conical pore is shaded. Left panel view from side, right panel view from extracellular aspect.