Figure 6.

Inhibitor concentrations required to reduce the virus adhesion to given normalized fractions for different HA-SA affinities. Even when the affinity of receptor-ligand binding is high, a moderate inhibitor concentration relative to the inhibition constant is sufficient to drastically reduce viral adhesion. (Dashed line) Inhibitor concentration required to reduce the equilibrium number of connections, $\overline{n}$, to <1. The inhibitor concentration required for $\overline{n}$ ≤ 1 is greater than that required to reduce the fraction of bound virus by 1000-fold, which suggests that adhesion can be effectively inhibited before $\overline{n}$ ≈ 0.