Table 1.
Age, sex, and genotype frequencies of the cases and controls n (%)
| Variable | Cases | Controls | P value1 |
| n = 727 | n = 736 | ||
| Age (mean ± SD), yr | 60.3 ± 12.8 | 60.7 ± 13.0 | 0.639 |
| Gender | 0.751 | ||
| Male | 410 (56.4) | 409 (55.6) | |
| Female | 317 (43.6) | 327 (44.4) | |
| Colon/rectum, n | 352/375 | ||
| OGG1 Ser326Cys | 0.021 | ||
| Ser/Ser | 93 (13.0) | 125 (17.1) | |
| Ser/Cys | 363 (50.8) | 324 (44.4) | |
| Cys/Cys | 258 (36.1) | 281 (38.5) | |
| Missing | 13 | 6 | |
| OGG1 11657A/G | 0.318 | ||
| A/A | 648 (91.9) | 654 (90.1) | |
| A/G | 55 (7.8) | 72 (9.9) | |
| G/G | 2 (0.3) | 0 (0.0) | |
| Missing | 22 | 10 | |
| OGG1 Arg154His | 0.158 | ||
| Arg/Arg | 720 (100.0) | 720 (99.7) | |
| Arg/His | 0 (0.0) | 2 (0.3) | |
| His/His | 0 (0.0) | 0 (0.0) | |
| Missing | 7 | 14 | |
| APE1 Asp148Glu | 0.567 | ||
| Asp/Asp | 236 (33.0) | 249 (34.3) | |
| Asp/Glu | 349 (48.8) | 361 (49.7) | |
| Glu/Glu | 130 (18.2) | 117 (16.1) | |
| Missing | 12 | 9 | |
| APE1 T-656G | 0.876 | ||
| T/T | 217 (30.1) | 211 (28.9) | |
| T/G | 368 (51.0) | 380 (52.0) | |
| G/G | 136 (18.9) | 140 (19.2) | |
| Missing | 6 | 5 |
1
Continuous variables were tested by Student’s t-test, and categorical variables were tested by χ2 or Mantel-Haenszel χ2 test.