Table 3.
Odds ratio and 95%CI of two OGG1 single nucleotide polymorphisms for colorectal cancer stratified by sex, age at diagnosis, and tumor site and stage
|
OGG1 Ser326Cys |
OGG1 11657A/G |
|||||||
|
Ser/Ser |
Ser/Cys + Cys/Cys |
A/A |
A/G + G/G |
|||||
| No.1 | OR (95%CI)2 | No.1 | OR (95%CI)2 | No.1 | OR (95%CI)2 | No.1 | OR (95%CI)2 | |
| Gender | ||||||||
| Male | 50/67 | 1.00 (ref) | 350/340 | 1.38 (0.93-2.05) | 364/358 | 1.00 (ref) | 31/47 | 0.65 (0.40-1.05) |
| Female | 43/58 | 1.00 (ref) | 271/265 | 1.38 (0.90-2.12) | 284/296 | 1.00 (ref) | 26/25 | 1.09 (0.61-1.93) |
| Age at diagnosis (yr) | ||||||||
| ≤ 60 | 44/54 | 1.00 (ref) | 275/264 | 1.28 (0.83-1.97) | 292/283 | 1.00 (ref) | 23/32 | 0.70 (0.40-1.22) |
| > 60 | 49/71 | 1.00 (ref) | 346/341 | 1.47 (0.99-2.17) | 356/371 | 1.00 (ref) | 34/40 | 0.89 (0.55-1.43) |
| Tumor site | ||||||||
| Colon | 45/125 | 1.00 (ref) | 299/605 | 1.39 (0.96-2.01) | 316/654 | 1.00 (ref) | 23/72 | 0.67 (0.41-1.09) |
| Rectum | 48/125 | 1.00 (ref) | 322/605 | 1.39 (0.97-1.99) | 332/654 | 1.00 (ref) | 34/72 | 0.93 (0.61-1.43) |
| Stage | ||||||||
| 0, I, II | 46/125 | 1.00 (ref) | 283/605 | 1.28 (0.88-1.84) | 307/654 | 1.00 (ref) | 20/72 | 0.59 (0.35-0.98)a |
| III, IV | 47/125 | 1.00 (ref) | 338/605 | 1.48 (1.03-2.13)a | 341/654 | 1.00 (ref) | 37/72 | 0.99 (0.65-1.51) |
1
Number of cases/number of controls;
2
Adjustment for age and sex (except in gender stratification, where only sex was adjusted for). The
a
P < 0.05 is the comparison between CRC patients in stage 0, I, II and controls in calculating OR for A/G + G/G genotype vs A/A genotype.