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. 2016 Mar 24;6:23472. doi: 10.1038/srep23472

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Copyright © 2016, Macmillan Publishers Limited

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(A) Time-dependent expression changes of BNIP3 under hypoxia. The expression of BNIP3 and miR-182 were compared at matching time points. *p < 0.05 compared to control. ^#p < 0.05 compared to control. (B) Effect of anti-miR-182 on miR-182-induced down regulation of BNIP3. *p < 0.05 compared to normal control. **p < 0.05 compared to hypoxia only. (C) Luciferase assay using 3′UTR of BNIP3. miR-Neg: negative control miRNA. *p < 0.05. The luciferase activity of the cells only transfected with each vector served as controls for each vector group with relative value of 1.