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. 2015 Dec 12;2(2):131–157. doi: 10.1016/j.jcmgh.2015.11.009

Figure 6.

Figure 6

Trafficking of ezrin-positive inclusions and DPPIV. (A) Duodenum from control and MYO5B KO mice were co-stained for ezrin (green) and Lamp2 (red). In control enterocytes, Lamp2-positive lysosomes concentrated just under the apical surface. Upon MYO5B loss, a subset of ezrin-positive inclusions were surrounded closely or cupped by Lamp2-positive lysosomes (arrowheads). However, other ezrin-positive inclusions were not located near Lamp2 (arrows). Scale bars: 25 μm. (B) In controls, the small DPPIV population occasionally found in the subapical region co-localized with Lamp2. *In MYO5B KO duodenum, the subset of DPPIV that mistrafficked to small punctate vesicles was found to co-label with Lamp2. Scale bars: 25 μm.