Table 3.
COPD cis eQTL Lead SNPs for CHRNA3, IREB2 and PSMA4 in the 15q25 locus
| SNP | MAF | Position (bp) | eQTL Genes | Probeset | eQTL q-value | eQTL tissue |
|---|---|---|---|---|---|---|
| rs138544659 | 0.36 | 78900701 | PSMA4 | 203396_at | <0.001 | Sputum |
| CHRNA3 | 211587_x_at | <0.001 | Blood | |||
| IREB2 | 1555476_at | 0.003 | Blood | |||
| IREB2 | 1555476_at | 0.026 | Sputum | |||
| IREB2 | 214666_x_at | 0.017 | Blood | |||
| rs10519203 | 0.37 | 78814046 | PSMA4 | 203396_at | <0.001 | Sputum |
| CHRNA3 | 211587_x_at | <0.001 | Blood | |||
| IREB2 | 214666_x_at | <0.001 | Blood | |||
| IREB2 | 1555476_at | 0.002 | Blood | |||
| IREB2 | 1555476_at | 0.030 | Sputum | |||
| rs1062980 | 0.37 | 78792527 | IREB2 | 1555476_at | <0.001 | Blood |
| IREB2 | 1555476_at | <0.001 | Sputum | |||
| IREB2 | 214666_x_at | 0.063 | Blood | |||
| rs1394371 | 0.31 | 78724469 | IREB2 | 1555476_at | <0.001 | Blood |
| IREB2 | 214666_x_at | <0.001 | Blood | |||
| CHRNA3 | 211587_x_at | 0.001 | Blood | |||
| WDR61 | 221531_at | 0.039 | Blood | |||
| IREB2 | 1555476_at | 0.089 | Sputum |
Position (bp)—genomic base-pair position in hg19.