Table I.
Methodological characteristics of the five dose-finding methods we compared.
| Method | YYC | CDP | BW | WCO | HHM |
|---|---|---|---|---|---|
| Estimation | Bayesian | Hwang and Peddada [26] | Bayesian | Likelihood | Likelihood |
| Parametric dose-toxicity model | Copula | None | Hierarchical | Power | Shrinkage |
| Prior toxicity probability specification | Yes | No | Yes | Yes | No |
| Inclusion of interactive effect in the model | Yes | No | No | No | Yes |
| Cohort size used in the original paper | 3 | 1 | 1 | 1 | 3 |
| Restriction skipping on dose levels | One dose level of change only and not allowing a simultaneous escalation or de-escalation of both agents | Same as the YYC method | One dose level of change only but allowing a simultaneous escalation or de-escalation of both agents | No skipping restriction | Same as the YYC method |