Skip to main content
. Author manuscript; available in PMC: 2016 Mar 24.
Published in final edited form as: Stat Med. 2015 May 13;34(24):3194–3213. doi: 10.1002/sim.6533

Table IV.

The recommendation rates for true maximum tolerated dose combinations (MTDCs) and over-dose combinations (ODCs) on average with respect to each type of the dose combination matrix, and position and number of true MTDCs. (The percentages for the best method are in bold).

Rec % for true MTDCs Rec % for ODCs


Dose combination matrix Position and number of true MTDCs Scenario YYC CDP BW WCO HHM YYC CDP BW WCO HHM
Square (i.e., 3 × 3 and 4 × 4) Diagonal and ⩾2 true MTDCs 1, 2, 5 58 74 58 69 58 24 17 23 20 16
Non-diagonal and ⩾2 true MTDCs 6, 7 39 45 33 38 40 37 38 33 33 22
1 true MTDC 3, 4, 8 12 26 28 28 32 60 37 42 48 39
Rectangle (i.e., 2 × 4 and 3 × 5) Diagonal and ⩾2 true MTDCs 9, 13 35 52 39 44 39 25 28 27 19 14
Non-diagonal and ⩾2 true MTDCs 10, 14, 15 35 39 38 44 44 44 20 40 32 25
1 true MTDC 12, 16 2 25 30 31 21 51 32 34 35 31
Avg allocation to true MTDCs (#) Accuracy index
Square (i.e., 3 × 3 and 4 × 4) Diagonal and ⩾2 true MTDCs 1, 2, 5 11 16 13 15 11 0.57 0.72 0.54 0.65 0.54
Non-diagonal and ⩾2 true MTDCs 6, 7 10 7 7 8 5 0.36 0.62 0.49 0.53 0.54
1 true MTDC 3, 4, 8 2 7 7 6 6 0.45 0.54 0.48 0.56 0.59
Rectangle (i.e., 2 × 4 and 3 × 5) Diagonal and ⩾2 true MTDCs 9, 13 6 9 9 10 7 0.46 0.60 0.46 0.58 0.51
Non-diagonal and ⩾2 true MTDCs 10, 14, 15 7 13 7 10 8 0.51 0.64 0.44 0.58 0.52
1 true MTDC 12, 16 1 10 5 7 4 0.35 0.59 0.51 0.58 0.48