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. 2016 Feb 15;2:16005. doi: 10.1038/cddiscovery.2016.5

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Copyright © 2016 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mitochondrial caspase-2 can trigger apoptosis in cell-free systems. Rat liver nuclei and Xenopus oocyte cytosol were mixed with purified mitochondria from (a) WT or Casp2^−/− brain or (b) WT or Casp2^−/− liver and incubated at 37˚C for 4 h. Shown are the apoptotic potency ratios (calculated as the percent ratio of apoptotic nuclei in sample to buffer) from three independent experiments. (c) Representative images of liver nuclei mixed with cytoplasmic and mitochondrial fractions from either WT or Casp2^−/− mice at 4 h. Upper panels are magnified images of the insets indicated in the respective lower panels. Panels 1–4 contain WT cytoplasmic fraction whereas panels 5–8 contain Casp2^−/− cytoplasmic fraction. (d) Apoptotic potency ratios of the different combinations at the indicated time points.