Table 1.
The up-regulated expression profiling of genes related to apoptosis in ACFP-treated human primary ovarian cancer cells in vitro
| Genebank ID | Gene symbol | Gene description | Ratio (ACFP/control) | |
|---|---|---|---|---|
| Low dose | High dose | |||
| NM_000581 | BAX | BCL2-associated X protein | 3.73 | 6.35 |
| NM_000836 | CASP3 | caspase 3, apoptosis-related cysteine peptidase | 3.72 | 5.34 |
| NM_008106 | PABPN1 | poly(A) binding protein, nuclear 1 | 3.71 | 9.8 |
| NM_001164 | CKS2 | CDC28 protein kinase regulatory subunit 2 | 3.67 | 8.95 |
| NM_007920 | BAT5 | HLA-B associated transcript 5 | 3.66 | 7.48 |
| NM_010653 | SPINT2 | serine protease inhibitor, Kunitz type, 2 | 3.58 | 10.25 |
| NM_001855 | DVL1 | dishevelled segment polarity protein 1 | 3.58 | 2.46 |
| NM_114904 | C1QTNF6 | C1q and tumor necrosis factor related protein 6 | 3.57 | 6.26 |
| NM_002949 | GSTM5 | glutathione S-transferase M5 | 3.55 | 4.84 |
| NM_007132 | TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 3.50 | 2.15 |
| NM_007132 | TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 3.50 | 2.08 |
| NM_055970 | GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | 3.49 | 8.30 |
| NM_009736 | USP34 | ubiquitin specific protease 34 | 3.49 | 4.52 |
| NM_441241 | LOC441241 | similar to chaperonin containing TCP1, subunit 6A (zeta 1); chaperonin containing T-complex subunit 6 | 3.48 | 5.22 |
| NM_114904 | C1QTNF6 | C1q and tumor necrosis factor related protein 6 | 3.43 | 6.26 |
| NM_051275 | FLJ39616 | apoptosis-related protein PNAS-1 | 3.34 | 2.53 |
| NM_009618 | TRAF4 | TNF receptor-associated factor 4 | 3.34 | 3.62 |
| NM-016522 | TMEFF1 | transmembrane protein with EGF-like and two follistatin-like domains 1 | 3.33 | 7.91 |
| NM_079829 | FLJ13848 | hypothetical protein FLJ13848 | 3.28 | 9.45 |
| NM-009774 | BTF/BCLAF1 | BCL2-associated transcription factor 1 | 3.25 | 2.79 |
| NM-006777 | STAT5B | signal transducer and activator of transcription 5B | 3.24 | 2.03 |
| NM_001026 | CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3.24 | 6.58 |
| NM_001026 | CDKN1A/p21 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3.24 | 3.58 |
| NM_003665 | IRF7 | interferon regulatory factor 7 | 3.13 | 4.50 |
| NM_081788 | SNARK | likely ortholog of rat SNF1/AMP-activated protein kinase | 3.08 | 3.11 |
| NM_000390 | ARHE | ras homolog gene family, member E | 2.99 | 3.39 |
| NM_005696 | PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) | 2.97 | 3.24 |
| NM_005603 | MAPK13/p38 delta | mitogen-activated protein kinase 13 | 2.91 | 3.04 |
| NM_010209 | SUI1 | putative translation initiation factor | 2.89 | 9.85 |
| NM-004824 | NKX3-1 | NK3 transcription factor related, locus 1 (Drosophila) | 2.8 | 3.11 |
| NM_005569 | PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 2.52 | 2.74 |
| NM_009950 | GOLGA5 | golgi autoantigen, golgin subfamily a, 5 | 2.46 | 2.95 |
| NM_079370 | BCL2L14 | BCL2-like 14 (apoptosis facilitator) | 2.44 | 2.57 |
| NM_008795 | TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 2.43 | 4.85 |
| NM_029775 | CARD10 | caspase recruitment domain family, member 10 | 2.43 | 4.32 |
| NM_002948 | GSTM4 | glutathione S-transferase M4 | 2.25 | 2.72 |
| NM_079092 | CARD14 | caspase recruitment domain family, member 14 | 2.13 | 3.06 |
| NM_007559 | ZNF12 | zinc finger protein 12 (KOX 3) | 2.07 | 3.66 |
| NM-006778 | STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | 2.06 | 10.8 |
| NM_000943 | TNFRSF8 | tumor necrosis factor receptor superfamily, member 8 | 2.05 | 3.22 |
| NM_005599 | MAPK8/JNK1 | mitogen-activated protein kinase 8 | 2.04 | 2.74 |
| NM_000943 | TNFRSF8 | tumor necrosis factor receptor superfamily, member 8 | 2.02 | 3.22 |
| NM_000714 | C1QG | complement component 1, q subcomponent, gamma polypeptide | 2.02 | 2.68 |
| NM_009262 | STK17B | serine/threonine kinase 17b (apoptosis-inducing) | 2.01 | 2.97 |