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. 2016 Mar 24;16:245. doi: 10.1186/s12885-016-2265-6

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© Huang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Honokiol inhibits colony formation and induces apoptosis via Bax/Bcl-2 and caspase-3-dependent pathway in SP-derived sphere cells. a Honokiol inhibited colony formation of the SAS and OECM-1 SP-derived sphere cells in a dose-dependent manner. The colony formation data are expressed as percent of control (without honokiol treatment) cells and shown as mean ± SD. *p < 0.05; **p < 0.01, significant difference vs. control. b Honokiol induced apoptosis of the SAS and OECM-1 SP-derived spheres in a dose-dependent manner. Apoptosis was determined by Annexin V-FITC/PI double staining and flow cytometry analysis. The honokiol concentration is shown in the right side of dot plots. The numbers in LR (lower right) quadrant indicates the percentage of early apoptotic cells. The numbers in UR (upper right) quadrant indicates the percentage of late apoptotic cells. c Dose-dependent effect of honokiol on the protein levels of Bax and Bcl-2. d Dose-dependent effect of honokiol on cleavage of caspase-3