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. 2016 Mar 24;16:245. doi: 10.1186/s12885-016-2265-6

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© Huang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Honokiol inhibits the JAK2/STAT3, Akt and Erk pathways in SP-derived spheres. The SAS SP-derived spheres were incubated with 5 or 10 μM honokiol for 48 h. The protein levels of total and phosphorylated JAK2 (a), STAT3 (b), Akt (c) and Erk (d) were determined by Western blot and quantified by densitometry. The ratios of pJAK2, pSTAT3, pAkt and pErk to actin were calculated