Fig. 7.

Honokiol dose-dependently inhibits growth of SAS SP cells xenograft in NOD/SCID mice. Mice were inoculated subcutaneously with 5 × 10³ SAS SP cells. Honokiol was administered by intraperitoneal injection thrice a week. a Tumor volumes were measured once a week. The tumor growth was dose-dependently inhibited by honokiol. *p < 0.05; **p < 0.01, significant difference vs. control. b At the end of week 10, the tumors were harvested and weighed. Honokiol dose-dependently decreased the tumor weight. Data shown are mean ± SD (n = 5). **p < 0.01, significant difference vs. control. c The changes of body weight were measured weekly after honokiol treatment. No significant difference between control and honokiol-treated groups was observed