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. 2016 Mar 24;16:245. doi: 10.1186/s12885-016-2265-6

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© Huang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Honokiol markedly decreases the immunohistochemical staining of PCNA and CD31 in SAS SP xenograft tumor tissue. Immunohistochemistry staining of PCNA and CD31 was performed in the paraffin-embedded tissue sections of tumors from mice treated with or without honokiol (80 mg/kg). a The staining intensity (brown color) of PCNA was markedly lower in honokiol-treated group. b The PCNA labeling indexes of control and honokiol-treated groups. c The staining intensity of CD31 (endothelial cell marker) was markedly lower in honokiol-treated group. d The number of CD31 positive microvessel was counted at 200x magnification under a microscope. Significantly reduced microvessel density (MVD)/fields was observed in honokiol-treated group. Data shown are mean ± SD. **p < 0.01; ***p < 0.001, significant difference vs. control