Table 1.
Enrichment analysis of top ten GO terms for genes in four clusters
| Term | Count | P value | Genes | |
|---|---|---|---|---|
| Cluster 1 | GO: 0006355~regulation of transcription, DNA-dependent | 8 | 4.53E−02 | PITX2, MSX2, DLX3, IRX3, ZNF181, SMAD9, DMRT2, ETV4 |
| GO: 0051252~regulation of RNA metabolic process | 8 | 5.03E−02 | PITX2, MSX2, DLX3, IRX3, ZNF181, SMAD9, DMRT2, ETV4 | |
| GO: 0016337~cell–cell adhesion | 3 | 9.79E−02 | REG3A, CLDN1, CDH3 | |
| GO: 0030574~collagen catabolic process | 2 | 3.78E−02 | KLK6, MMP7 | |
| GO: 0044243~multicellular organismal catabolic process | 2 | 4.88E−02 | KLK6, MMP7 | |
| GO: 0032963~collagen metabolic process | 2 | 5.25E−02 | KLK6, MMP7 | |
| GO: 0044259~multicellular organismal macromolecule metabolic process | 2 | 5.80E−02 | KLK6, MMP7 | |
| GO: 0044236~multicellular organismal metabolic process | 2 | 6.88E−02 | KLK6, MMP7 | |
| GO: 0042552~myelination | 2 | 7.06E−02 | KLK6, CLDN1 | |
| GO: 0007272~ensheathment of neurons | 2 | 7.77E−02 | KLK6, CLDN1 | |
| Cluster 2 | GO: 0007586~digestion | 3 | 2.69E−02 | CAPN9, TFF2, TFF1 |
| GO: 0002526~acute inflammatory response | 3 | 3.08E−02 | SERPINA1, C4BPA, LBP | |
| GO: 0010038~response to metal ion | 3 | 5.07E−02 | XDH, SERPINA1, TFF1 | |
| GO: 0045087~innate immune response | 3 | 5.72E−02 | C4BPA, LBP, DEFB1 | |
| GO: 0008544~epidermis development | 3 | 9.41E−02 | COL17A1, LAMA3, RBP2 | |
| Cluster 3 | GO: 0006955~immune response | 30 | 3.03E−15 | ITGAL, IL16, LY86 |
| GO: 0045321~leukocyte activation | 16 | 1.67E−10 | ITGAL, CD3G, TNFSF4 | |
| GO: 0001775~cell activation | 16 | 1.79E−09 | ITGAL, CD3G, TNFSF4 | |
| GO: 0006952~defense response | 16 | 3.00E−05 | ITGAL, TNFSF4, AIF1 | |
| GO: 0042110~T cell activation | 15 | 2.58E−13 | ITGAL, CD3G, TNFSF4 | |
| GO: 0046649~lymphocyte activation | 15 | 1.35E−10 | ITGAL, CD3G, TNFSF4 | |
| GO: 0008283~cell proliferation | 11 | 1.12E−03 | HHEX, STAT4, DOCK2 | |
| GO: 0042127~regulation of cell proliferation | 11 | 5.52E−02 | HHEX, CORO1A, TNFSF4 | |
| GO: 0007610~behavior | 10 | 6.45E−03 | CORO1A, DOCK2, IL16 | |
| GO: 0009611~response to wounding | 10 | 1.37E−02 | ITGAL, TNFSF4, AIF1 | |
| Cluster 4 | GO: 0006334~nucleosome assembly | 9 | 3.17E−08 | HIST2H2AA3, HIST4H4, HIST1H1E |
| GO: 0031497~chromatin assembly | 9 | 4.19E−08 | HIST2H2AA3, HIST4H4, HIST1H1E | |
| GO: 0065004~protein-DNA complex assembly | 9 | 5.98E−08 | HIST2H2AA3, HIST4H4, HIST1H1E | |
| GO: 0034728~nucleosome organization | 9 | 7.10E−08 | HIST2H2AA3, HIST4H4, HIST1H1E | |
| GO: 0006323~DNA packaging | 9 | 4.24E−07 | HIST2H2AA3, HIST4H4, HIST1H1E | |
| GO: 0007155~cell adhesion | 18 | 5.34E−07 | EMCN, NRP1, CCL2 | |
| GO: 0022610~biological adhesion | 18 | 5.45E−07 | EMCN, NRP1, CCL2 | |
| GO: 0006333~chromatin assembly or disassembly | 9 | 7.96E−07 | HIST2H2AA3, HIST4H4, HIST1H1E | |
| GO: 0009611~response to wounding | 14 | 1.26E−05 | C3AR1, CCL3, IL6 | |
| GO: 0001568~blood vessel development | 9 | 9.73E−05 | VEGFC, EMCN, NRP1 |
GO gene ontology