Table 1. Elk dam and fetus pairs from CWD endemic area of Colorado: summary of results.
Br, Brain; Ob, obex; Ut, uterus; Pl, placentome; Ct, cotyledon; RLN, retropharyngeal lymph node; Sp, spleen; To, tongue; Ad, adipose tissue; MG, mammary gland; Bl, urinary bladder; K, kidney; Pa, pancreas; NE, nasal epithelium; SG, salivary gland; Ur, ureter; Ov, ovary; RAMALT, rectal mucosa-associated lymphoid tissue. Italics denote sPMCA+ CWD amplification and the five items in bold denote that the IHC and sPMCA data corroborate one another.
| Maternal IHC status | Dam PRNP codon 132 genotype | Maternal sPMCA-positive tissues | Maternal positive/total samples | Gestation trimester | Fetal PRNP codon 132 genotype | Fetal positive/total samples |
|---|---|---|---|---|---|---|
| Negative | MM | None | 0/18 | Second | MM | 0/3 |
| Negative | ML | None | 0/16 | Second | MM | 0/11 |
| Negative | MM | None | 0/18 | First | ML | 0/6 |
| Negative | ML | None | 0/18 | First | MM | 0/5 |
| Positive (Ob, RLN)* | MM | Br, Ob, RAMALT, RLN, Sp, Ut, Ov, Ur, To, Bl, K, Pa, NE, SG | 14 (C+L + R + S)/18 | Second | MM | 1 (colon)/10 |
| Positive (Ob, RLN)* | MM | Ob, RLN, Um, Ov, To, Bl, K, Pa, SG, Ad | 6 (C+L + R + S)/17 | Second | ML | 1 (lung)/6 |
| Negative | ML | Ob, RAMALT, Um, Ov, Ur, Ad | 10 (C+L + R + S)/18 | Second | ML | 5 (vagus nerve, spleen, colon, thymus, liver)/11 |
| Negative | ML | Br, To, Bl, K, Ad | 5 (C+S)/19 | Second | MM | 2 (RLN, thymus)/10 |
| Negative | MM | Br, Ob, SG | 3 (C+S)/19 | Second | MM | 2 (brain, ileum)/6 |
| Positive (RLN)† | MM | RLN, Pl, Ct Um, NE, Ur | 6(L+R + S)/15 | Second | MM | 2 (RLN, liver)/9 |
| Negative | ML | RAMALT, Spl Ut, Ct, Um, K | 6(L+R + S)/18 | Second | ML | 1 (spleen)/7 |
| Negative | MM | Ut, To, K, SG, MG | 5 (R+S)/11 | Second | MM | 1 (rectum)/8 |
| Negative | MM | Pl, Bl, NE, Ur | 4(R+S)/16 | Second | MM | 1 (popliteal lymph node)/7 |
| Negative | ML | Pl, Bl, NE, Ur | 4 (R+S)/16 | Second | MM | 0/7 |
| Negative | MM | Pl, Bl | 2 (R+S)/18 | Second | ML | 0/11 |
| Negative | ML | Ob, Um, NE | 3(C+R + S)/19 | First | MM | 1 (vagus nerve)/6 |
| Negative | MM | Ut, Pl, To, K, NE, Ad, MG | 7 (R+S)/17 | First | MM | 1 (ileum)/8 |
| Negative | ML | Sp, Ov | 2 (L+R)/18 | First | ML | 1 (thymus)/8 |
| Negative | ML | Br, Ob, Sp, Um | 4(C+L + R)/18 | First | MM | 0/3 |
*
IHC: obex-positive, RLN-positive.
†
IHC: obex-negative, RLN-positive.