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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Transfus Clin Biol. 2015 Jun 6;22(3):178–181. doi: 10.1016/j.tracli.2015.05.005

Fig. 2.

Fig. 2

Working model HO-1 basal levels in monocytes is critical in T cell polarization in response to hemin/transfused RBCs. Secretion of pro-inflammatory (IL-12) by monocytes in response to transfused RBCs/hemin will depend on the baseline HO-1 levels. Higher Treg/T effector ratios will suppress T cell activation and B cell humoral immunity whereas lower Treg/T effector ratios will trigger alloimmunization.