See Sorg and Grothe (doi:10.1093/brain/awv302) for a scientific commentary on this article.

Early studies reported inconsistencies between amyloid plaque location and regional dysfunction implied by clinical course. Recent PET studies, however, highlight the overlap between amyloid deposition and regions affected early in Alzheimer’s disease. Altmann et al. report that regional hypometabolism is in fact related to cortex-wide rather than regional plaque burden.