Table 1.
Relative standard deviation for fitted metabolic rates obtained by Monte-Carlo simulation with the positional and the bonded cumomer models, for the three infusion protocols: [1,6-13C]glucose only, [1,2-13C]acetate only, and [1,6-13C]glucose and [1,2-13C]acetate simultaneously, without glutamine dilution (VDILGLN = 0) and with glutamine dilution (VDILGLN = 0.1). Monte-Carlo simulations were performed with 20 experimental points per curve, tmax =150 min, noise σ = 0.2 μmol.g−1.
| [1,6-13C2]Glucose | [U-13C]acetate | [1,6-13C2]Glucose + [U-13C]acetate | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| without gln dilution | with gln dilution | without gln dilution | with gln dilution | without gln dilution | with gln dilution | |||||||
| positional | cumomer | positional | cumomer | positional | cumomer | positional | cumomer | positional | cumomer | positional | cumomer | |
| VTCA(N) | 7% | 5% | 7% | 6% | 22% | 14% | 46% | 45% | 6% | 4% | 6% | 5% |
| VTCA(A) | 52% | 43% | 61% | 49% | 16% | 9% | 25% | 13% | 20% | 9% | 36% | 12% |
| VNT | 77% | 17% | 22% | 15% | 11% | 9% | 39% | 30% | 19% | 8% | 20% | 9% |
| VPC | 12% | 9% | 19% | 12% | 14% | 9% | 36% | 27% | 7% | 4% | 12% | 6% |
| VX | 19% | 14% | 20% | 13% | 24% | 12% | 71% | 18% | 18% | 9% | 18% | 9% |
| VOUT | 7% | 6% | 17% | 10% | n/a | n/a | n/a | n/a | 9% | 6% | 13% | 9% |
| VDILGLN | n/a | n/a | 19% | 11% | n/a | n/a | 98% | 70% | n/a | n/a | 15% | 9% |