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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: Eur J Pharmacol. 2016 Feb 9;775:149–158. doi: 10.1016/j.ejphar.2016.02.031

Figure 4. Assessment of direct gating effects of meprobamate in extrasynaptic GABAA receptors.

Figure 4

A, representative traces demonstrating meprobamate direct gating action on α4β3δ and α1β3δ GABAA receptors, in comparison to a saturating concentration of GABA. The maximal efficacy of meprobamate was comparable to that of GABA. B, Summary data illustrating the efficacy of meprobamate compared to GABA in α1β2, α1β2γ2, α1β3δ and α4β3δ GABAA receptor. Data for α1β2 and α1β2γ2 receptors are replotted from Figure 1 for comparison. Efficacy of the full agonist THIP was also assessed; it was significantly more efficacious than either GABA or meprobamate on δ-containing GABAA receptors. Each bar represents the mean ± S.E.M. of a minimum of 3 cells for δ-containing receptors, and mean ± S.E.M. of a minimum of 4 for all others. *, P < 0.05; **, P < 0.01.