Table 1.
Bioactivities of the Ets.
| IC50 (ng/mL) | IC50 (µg/mL) | µg/dics | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L1210 | P388 | A549 | HT29 | MEL28 | CV-1 | PS | DNA | RNA | DNAp | RNAp | Bs | |
| Et-743 | 5.0 | 0.2 | 0.2 | 0.5 | 5.0 | 1.0 | >1 | 0.1 | 0.03 | 2.0 | 0.1 | 0.02 |
| Et-729 | <1.0 | 0.2 | 0.2 | 0.5 | 5.0 | 2.5 | >1 | 0.2 | 0.02 | 1.5 | 0.05 | 0.08 |
| Et-815 | 25 | 2.5 | 5.0 | 5.0 | 5.0 | >1 | 0.1 | 5.0 | 0.75 | |||
| Et-759B | 5.0 | 5.0 | 5.0 | 10 | 25 | >1 | 0.7 | 0.5 | >1 | 3.90 | ||
| Et-745B | 25 | 5.0 | 10 | 10 | 25 | >1 | 0.5 | 3.0 | ||||
| Et-759C | 1.0 | 2.5 | 2.5 | 2.5 | 2.5 | >1 | 0.5 | >5 | 0.1 | |||
| Et-745 | 10 | 20 | 25 | 50 | 50 | >1 | 0.3 | 5.0 | 6.50 | |||
| Et-731 | 100 | 100 | 100 | 200 | 200 | >1 | 6.20 | |||||
| Et-736 | 0.5 | 1.0 | 2.5 | 2.5 | 2.5 | 0.5 | 0.4 | 0.1 | 0.5 | 0.38 | ||
| Et-722 | 1.0 | 1.0 | 2.0 | 2.0 | 5.0 | 0.9 | 0.4 | 0.1 | >1 | 0.5 | 0.70 | |
| Et-594 | 10 | 20 | 25 | 25 | 25 | 0.8 | 0.5 | 0.5 | 1.0 | 0.37 | ||
| Et-597 | 2.0 | 2.0 | 2.0 | 2.0 | 2.5 | 0.7 | 0.08 | 0.01 | 0.25 | 0.14 | ||
| Et-583 | 10 | 10 | 10 | 5.0 | 25 | 1.0 | 1.0 | 0.4 | 0.5 | 0.74 | ||
L1210 = murine lymphocytic leukemia cells; P388 = murine lymphoblastic cells; A549 = human lung carcinoma; HT29 = human colon carcinoma; MEL28 = human melanoma; CV-1 = monkey kidney cells; PS = protein synthesis inhibition; DNA = DNA synthesis inhibition; RNA = RNA synthesis inhibition; DNAp = DNA polymerase inhibition; RNAp = RNA polymerase inhibition; Bs = Bacillus subtilis.