Table 1. Clinical characteristics of patients with NFMA and healthy age-matched control subjects.
| Parameter | NFMA | Controls | P-value |
|---|---|---|---|
| N | 15 | 15 | |
| No. of females | 8 (53%) | 5 (33%) | 0.269 |
| Age, median (range)(yr) | 58 (26–65) | 52 (30–63) | 0.220 |
| BMI (kg/m2) | 27.3 ± 4.1 | 25.3 ± 2.5 | 0.125 |
| Years after surgery | 6 (1–18) | ||
| Adjuvant radiotherapy | 5 (33%) | ||
| VFD at presentation | 12 (80%) | ||
| Suprasellar extension | 14 (93%) | ||
| Pituitary insufficiency | 11 (73%) | ||
| Intradaily variability of activity‡a | 0.43 ± 0.09 | 0.35 ± 0.08 | 0.014 |
| Altered melatonin profile‡b | 5 (33%) | 0 (0%) | 0.042 |
| Proximal skin temperature daytime‡c | 33.5 ± 0.6 | 33.9 ± 0.4 | 0.039 |
| Sleep characteristicsd | |||
| Sleep period (minutes) | 499.1 ± 92.7 | 477.5 ± 56.6 | 0.373 |
| Total sleep time (minutes) | 438.6 ± 101.5 | 448.0 ± 61.0 | 0.852 |
| Sleep efficiency (%) | 87.1 ± 8.2 | 93.1 ± 3.1 | 0.010 |
| % non-REM 1 of TST | 20.2 ± 10.3 | 9.6 ± 4.3 | <0.001 |
| % non-REM 2 of TST | 41.4 ± 9.2 | 41.4 ± 6.7 | 0.989 |
| % non-REM 3 of TST | 20.9 ± 9.4 | 23.4 ± 5.3 | 0.379 |
| % REM of TST | 17.4 ± 5.2 | 25.5 ± 4.3 | <0.001 |
| % WASO | 12.8 ± 8.1 | 6.3 ± 3.1 | 0.005 |
| PLM per hour | 18.9 ± 21.8 | 16.4 ± 7.3 | 0.296 |
| Apnea-hypopnea index | 3.7 ± 5.2 | 6.8 ± 6.2 | 0.074 |
| Mean apnea duration (seconds) | 13.4 ± 9.1 | 21.8 ± 8.0 | 0.008 |
| Desaturation periodse (%) | 0.2 (0.0–9.6) | 0.0 (0.0–0.9) | 0.075 |
Data represent number (percentage), average ± SD, or median (P10-P90), unless described otherwise.
aFrom 7 days of actigraphy recording [9].
bAbsence of evening rise or daytime values >3 pg/mL in a 36-hour salivary melatonin collection [10].
cFrom 24-hour skin temperature measurements [10].
dAssessed with polysomnography.
ePercentage of total sleep time in which saturation was below 90%.
VFD, Visual field defects; TST, total sleep time; WASO, wake after sleep onset; PLM, period limb movements. Statistically significant differences are marked in bold.