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. 2016 Mar 24;11(3):e0151652. doi: 10.1371/journal.pone.0151652

Table 3. Changes in functional capacity evaluated by cardiopulmonary exercise test (CPET) in patients in each group at baseline and at the end of the study (12 weeks).

Results are expressed as mean±standard error of the mean or frequencies (%).

  Exercise group Relaxation group
Baseline (n = 14) 12 weeks (n = 14) Baseline (n = 8) 12 weeksa (n = 5)
Total effort time (min) 8.5±0.6 10.5±0.6d 9.3±1.0 11.0±1.3
VATb time (min) 6.6±0.5 8.1±0.3e 5.1±1.2 7.5±1.7
Maximal heart rate (bpm) 129.1±5.0 137.9±3.5f 123.3±7.0 110.2±6.5
VO2peakc/kg weight (ml/kg/min) 21.4±0.8 23.0±1.3 23.5±2.9 25.0±3.2
Functional limitation evaluated by VO2peak 10/14 (71.4%) 6/14 (42.8%) 5/8 (62.5%) 3/5 (60%)

aOnly 5 patients were evaluated by CPET at 12 weeks.

bVAT: ventilatory anaerobic threshold.

cVO2peak: peak oxygen uptake.

dp<0.001

ep = 0.009 vs baseline in the exercise group.

fp = 0.01 vs baseline in the exercise group, and p = 0.001 vs 12 weeks in the relaxation group.

No other statistically significant differences were observed between groups at baseline or at 12 weeks, or between time points in each group.