Table 1. Bleeding episodes and transfusion events prior to gene therapy in privately owned dogs with severe hemophilia A.

Age	Bleeding event	Spontaneous or traumatic	Transfusion support
Dog 1
8 weeks	Hematoma in hindlimb	Spontaneous	None
9 weeks	Suspected hemothorax (cough and dyspnea)	Spontaneous	None
12 weeks	Hematoma on head	Spontaneous	CRYOa
20 weeks	Oral bleeding and ecchymoses on abdomen	Spontaneous	CRYO
21 weeks	Oral bleeding following loss of tooth	Spontaneous	CRYO
23 weeks	Hematomas on leg and neck	Spontaneous	CRYO
25 weeks	Hemarthrosis and hematoma on thorax; blood loss anemia	Spontaneous	CRYO
32 weeks	Scrotal hemorrhage after castration	Traumatic	CRYO, PRBCsb
40 weeks	Hemarthrosis and hematoma over shoulder	Spontaneous	CRYO
41 weeks	Hematoma on neck; blood loss anemia	Spontaneous	CRYO, PRBCs
46 weeks	Recurring hematoma over shoulder	Spontaneous	CRYO
50 weeks	Recurring hematoma over shoulder	Spontaneous	CRYO
Dog 2
8 weeks	Hematoma on head; blood loss anemia	Spontaneous	FWBc
10 weeks	Hematoma in hindlimb	Spontaneous	FFPd
23 weeks	Hematoma in hindlimb and epistaxis; blood loss anemia	Spontaneous	FWB
11 months	Severe melena following corticosteroid administration for allergies	Spontaneous	FWB
11.5 months	Hematoma in forelimb	Spontaneous	FWB
12–14 months	Recurring hematoma in hindlimb	Spontaneous	FWB or FFP on 5 separate occasions
17 months	Bleeding from sutures placed for conjunctival flap (corneal ulcer)	Traumatic	FFP
19 months	Hemarthrosis	Spontaneous	FFP
20 months	Epistaxis and gingival bleeding	Spontaneous	None
21 months	Epistaxis and gingival bleeding	Spontaneous	None
22 months	Hematoma in hindlimb	Spontaneous	FFP on 5 separate occasions during the month
24 months	Bleeding after microchip placement	Traumatic	None
25 months	Hematoma in hindlimb	Spontaneous	None

^aCRYO, cryoprecipitate

^bPRBCs, packed red blood cells

^cFWB, fresh whole blood

^dFFP, fresh frozen plasma.