Table 1. Demographics Summary.
| Cohort | LC | LC_Dyn | CC_Carrier | CC_Noncarrier | AQ_Carrier | AQ_Noncarrier | LNC |
|---|---|---|---|---|---|---|---|
| N | 59 | 23 | 38 | 31 | 21 | 20 | 36 |
| Age (SD) years | 42.6 (8.7) | 44.8 (10.8) | 38.4 (10.5) | 39.3 (9.5) | 37.4 (11.2) | 39.9 (9.1) | 41.3 (9.6) |
| EYO (SD) years | -2.1 (8.6) | -1.1 (11.3) | -8.8 (9.4) | -5.7 (10.9) | -10.0 (10.3) | -5.5 (9.6) | -4.5 (10.2) |
| Education (SD) years | 14.0 (2.8) | 15.0 (3.2) | 15.5 (3.1) | 15.5 (2.4) | 15.2 (2.6) | 15.5 (2.5) | 14.9 (2.2) |
| Interval (SD) years | 1.7 (0.8) | 1.9 (0.8) | - | - | - | - | 2.4 (0.9) |
| Male (%) | 30 (50.8) | 17 (73.9) | 27 (71.1) | 15 (48.4) | 16 (76.1) | 9 (45.0) | 14 (38.9) |
| APOE4+ (%) | 23 (39.0) | 11 (47.8) | 14 (36.8) | 10 (32.3) | 11 (52.3) | 5 (25.0) | 11 (30.6) |
| CDR>0 (%) | 28 (47.5) | 10 (43.5) | 11 (28.9)* | 0 (0) | 4 (19.0) | 0 (0) | 0 (0) |
| MMSE (SD) | 26.2 (5.2) | 28.2 (2.5)† | 28.2 (3.4)* | 29.6 (0.6) | 28.1 (3.1) | 29.4 (0.7) | 29.1 (1.1) |
LC = longitudinal cohort; CC_Carrier = cross-sectional cohort mutation carrier; CC_Noncarrier = cross-sectional cohort non-carrier; AQ_Carrier = absolute quantification cohort mutation carrier; AQ_Noncarrier = absolute quantification cohort non-carrier; LNC = longitudinal non-carrier cochort; baseline values were reported for LC and LNC; EYO = estimated years to onset; SD = standard deviation; APOE4+ = apolipoprotein E ε4 gene carrier; CDR = clinical dementia rating; MMSE = Mini Mental State Examination
*significantly different from corresponding non-carrier group
†significantly different from the LC group