Table 3. Regional volume of distribution (VT) estimated using image-derived arterial input function.

	MC	CER	BS	CW	TW	MCRSF	CERRSF	BSRSF	CWRSF	TWRSF
Noncarrier	2.79±1.00	2.75±0.98	3.66±1.27	3.71±1.49	3.35±1.26	3.16±1.14	2.83±1.02	4.20±1.45	4.13±1.81	3.90±1.56
Carrier	3.70±1.07	2.71±0.62	3.55±0.80	3.68±0.86	3.77±0.87	5.20±2.06	2.80±0.64	4.06±0.93	3.79±1.01	3.72±0.86
p	7.78E-03	8.83E-01	7.28E-01	9.22E-01	2.27E-01	4.17E-04	9.07E-01	7.14E-01	4.69E-01	6.54E-01

MC = mean cortical regions; CER = cerebellar cortex; BS = brainstem; CW = core white matter; TW = total white matter; MCRSF = mean cortical regions with RSF partial volume correction; CERRSF = cerebellar cortex with RSF partial volume correction; BSRSF = brainstem with RSF partial volume correction; CWRSF = core white matter with RSF partial volume correction; TWRSF = total white matter with RSF partial volume correction; p is the strength of the group difference, i.e. noncarrier vs. carrier, for each region of interest based on student t-test.