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. 2016 Mar 24;11(3):e0152234. doi: 10.1371/journal.pone.0152234

Fig 5. ChIP-seq read density profiles of GATA-1, PU.1 and H3K4me3 datasets at the PU.1 (Sfpi1) gene locus (-20kb upstream to 6kb downstream of PU.1 TSS).

Fig 5

The proximal promoter (PP, 0 to 500nt upstream the TSS), the URE (-13548bp; -14505bp) and conserved regions corresponding to the human genome are highlighted in vertical stripes and lines. (A) Occupancy of GATA-1 in MEL cells or MEL induce to differentiate by 2% DMSO for 5 days, or in Ter119+ Fetal liver (E14.5-derived) erythroblasts. The lowest panel shows occupancy by PU.1 in MEL cells. (B) Binding profiles of PU.1 and GATA1 in murine primary macrophages stimulated by lipopolysaccharide for 24hrs (MacrLPS), pro-B cells (38B9), and EsEP: differentiating murine ES cell-derived erythroid progenitors; (C) H3K4me3 occupancy in MEL and MEL+DMSO cells.