Fig 1. Estimated minimum annual human genome sequencing capacity based on sales of Illumina HiSeq X annual throughput capacity (at least 16 systems sold worldwide) and the amount of data available up to 2014 via dbGaP—one of the largest repositories for clinical human genomic data [12].

Taking into account that a whole genome sequence is ~200 GB in size, this corresponds to ~360,000 and ~3,000 human genomes, respectively [9,10,13].