Table 4.
Effects of adrenergic drugs on Nur77 expression in extra-striatal areas
| Veh | Prazosin | Idazoxan | Haloperidol | Prazosin+Hal | Idazoxan+Hal | |
|---|---|---|---|---|---|---|
| Nur77 mRNA levels (% of vehicle) | ||||||
| mPFC | 100±14 | 73±4 | 151±10 | 116±9 | 131±9 | 150±18 |
| CC | 100±16 | 62±16 | 125±16 | 109±11 | 124±8 | 148±9 |
| NAcS | 100±12 | 41±20* | 77±14 | 221±11*** | 216±4*** | 304±10***## |
| NAcC | 100±1 | 38±4** | 96±5 | 250±9*** | 197±6***## | 263±6*** |
| SNc | 100±23 | 132±35 | 141±20 | 772±80*** | 827±93*** | 1094±119***# |
| VTA | 100±18 | 113±18 | 104±11 | 475±60*** | 707±69***# | 618±55*** |
CC, Cingulate cortex ; Hal, haloperidol; mPFC, medial prefrontal cortex ; NAcC, nucleus accumbens core ; NAcS, nucleus accumbens shell ; SNc, substantia nigra pars compacta; VTA, ventral tegmental area ; Veh, vehicle.
Values represent mean±S.E.M. from five animals per group
p<0.05,
p<0.01,
p<0.001 vs. Veh group;
p<0.05,
p<0.01 vs. haloperidol group.