Table 2.
Pharmacokinetic parameters of the different formulations injected to rats (n = 8). Cmax is the maximal value of the rivastigmine plasmatic concentration and tmax the corresponding time. t1ng corresponds to the time when the rivastigmine concentration was less than 1 ng mL−1. AUC corresponds to the area under the plasma concentration vs. time curve between days 0 and the last day of the study.
| Formulation | Cmax (ng mL−1) | tmax (h) | t1ng (day) | AUC ± SD (h ng mL−1) |
|---|---|---|---|---|
| PK-Oil-300-5 | 4077 | 0.25 | 2 | 4100 ± 1900 |
| PK-BTM-300-15 | 397 | 0.25 | 9 | 8100 ± 6600 |
| PK-BTM-300-25 | 482 | 8 | 14 | 11,600 ± 10,100 |
| PK-BTM-500-25 | 334 | 8 | >35 | 14,700 ± 7000 |
| PK-SAM-300-15 | 758 | 12 | 11 | 20,300 ± 17,600 |