Table 1.

Effect of MPTP lesion and treatments on the dopamine transporter specific binding measured by autoradiography in the caudate nucleus and putamen of monkeys.

	[125I]RTI-121 specific binding (fmol/mg tissue)
	Dorsomedial	Ventromedial	Ventrolateral	Dorsolateral
Caudate nucleus
Control	1.081 ± 0.134	1.099 ± 0.208	0.957 ± 0.088	0.984 ± 0.063
MPTP	0.017 ± 0.007**	0.056 ± 0.024**	0.041 ± 0.017**	0.013 ± 0.004**
MPTP+L-Dopa	0.019 ± 0.005**	0.032 ± 0.010**	0.031 ± 0.010**	0.018 ± 0.005**
MPTP+L-Dopa+DHA	0.032 ± 0.010**	0.040 ± 0.010**	0.032 ± 0.010**	0.024 ± 0.010**
Putamen
Control	0.827 ± 0.057	0.783 ± 0.043	1.025 ± 0.086	1.030 ± 0.076
MPTP	0.093 ± 0.033**	0.102 ± 0.033**	0.060 ± 0.020**	0.060 ± 0.026**
MPTP+L-Dopa	0.067 ± 0.018**	0.106 ± 0.019**	0.070 ± 0.020**	0.040 ± 0.010**
MPTP+L-Dopa+DHA	0.097 ± 0.009**	0.119 ± 0.018**	0.066 ± 0.010**	0.050 ± 0.010**

Data represent means ± SEM.

^**p<0.01 vs respective control group.