Table 1.

The IC₅₀ values (µM) of drugs tamoxifen, doxorubicin, and cisplatin in MCF-7 parental and spheroids at 96 hours post-treatment. Cell survival was determined by MTT assay. All data are expressed as means ± SD. *p<0.05 when compared with the parental. The IC₅₀ were obtained from the dose-response curves for parental and spheroids treated with the different drugs respectively.

	IC50(µM)
	Tamoxifen	Doxorubicin	Cisplatin
MCF-7 Parental	20.57 ± 2.25	1.00 ± 0.37	2.54 ± 0.44
MCF-7 Spheroid (3D)	60.73 ± 7.39*	18.82 ± 3.05*	13.61 ± 3.54*
MCF-7 Spheroid (2D)	47.62 ± 6.83*	13.25 ± 3.69*	13.68 ± 3.92*

*P<0.05 compared to the parental group.