Table 2.
Summary results of DNA damage and repair.
| ND | MGH | GDM | DM2 | |||||
|---|---|---|---|---|---|---|---|---|
| DNA Damage | ||||||||
| nDNA | mtDNA | nDNA | mtDNA | nDNA | mtDNA | nDNA | mtDNA | |
| Mothers | ↑* | ↑* | ↑* | ↑* | ||||
| Newborns | ns | ns | ns | ns | ns | ns | ns | ns |
| DNA Repair | ||||||||
| mRNA | Protein | mRNA | Protein | mRNA | Protein | mRNA | Protein | |
| Mothers | ||||||||
| hOGG1 | nd | nd | nd | ↓§ | nd | |||
| APE1 | ↓* | ↓ | ↓* | |||||
| FEN1 | ns | ns | ↓*# | ns | ↓# | ns | ||
| POLβ | ↓* | ↓* | ↓* | |||||
| Newborns | ||||||||
| hOGG1 | nd | nd | nd | nd | ↑*# | |||
| APE1 | ↑ | ↑ | ||||||
| FEN1 | ↑* | ↑*# | ↑*# | |||||
| POLβ | ↑* | ↑ | ||||||
↑ increase of expression or ↓ decrease of expression compared to all groups; *compared to ND group; # compared to MGH group; § compared to DM2 group. nd: not detected; ns: not significant.