FIGURE 10.

INT-777 increases pancreatic β cell area in db/db mice. A, representative immunohistochemistry images (n = 5) of pancreatic tissue sections using antibodies against insulin (green) and glucagon (red). Effect of INT-777 on β cell area, expressed as % of pancreas area (B), pancreas area, expressed as μm² (C), α cell area, expressed as % of pancreas (D), and β cell area per islet, expressed as μm² (E) in wild type (Wt) and db/db mice with or without INT-777 treatment for 7 weeks. Data are expressed as the mean ± S.E. for 5 mice per group; *, p < 0.05, or **, p < 0.001, compared with db/db mice.